Is immunogenetic susceptibility to neuropsychiatric systemic lupus erythematosus (SLE) different from non-neuropsychiatric SLE?

Is immunogenetic susceptibility to neuropsychiatric systemic lupus erythematosus (SLE) different from non-neuropsychiatric SLE?

OBJECTIVES To analyse frequency of HLA class II antigens (DR and DQ) and lymphocytotoxic autoantibodies in patients with systemic lupus erythematosus (SLE) and subsets with or without neuropsychiatric involvement. METHODS Ninety three patients with SLE (42 with neuropsychiatric features) were typed for HLA class II antigens and investigated for the presence of lymphocytotoxic autoantibodies b...

Current concepts of neuropsychiatric systemic lupus erythematosus (NP-SLE).

Neuropsychiatric Systemic Lupus Erythematosus

Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps the most prevalent manifestation of lupus. The pathogenesis of NPSLE is multifactorial and involves various inflammatory cytokines, autoantibodies, and immune complexes resulting in vasculopathic, cytotoxic and autoantibody-mediated neuronal injury. The management of NPSLE is multimodal and has not been s...

Course of Neuropsychiatric Symptoms during Flares of Systemic Lupus Erythematosus (SLE)

We present the case of a seventeen-year-old girl who presents with an interesting course of neuropsychiatric symptoms during several flares of SLE. The patient was diagnosed at the age of thirteen and has had four flares in total. The latter two flares included cutaneous and neuropsychiatric symptoms. The most recent flare occurred when she was aged seventeen. She had cutaneous symptoms which c...

The interface between medicine and psychiatry: neuropsychiatric aspects of systemic lupus erythematosus (SLE).

1Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Address for Correspondence: Dr Roger C Ho, Department of Psychological Medicine, Level 9, NUHS Tower Block, 1E Kent Ridge Road, Singapore 119228. Email: [email protected] Systemi...